Disha Narang, an endocrinologist and the director of Obesity Medicine at Northwestern Lake Forest Hospital in Illinois, told The Post compounded semaglutide is not FDA approved and we dont have any data on long-term efficacy. Furthermore, she said Eli Lilly and Novo Nordisk, the makers of diabetes drugs tirzepatide and semaglutide, are going to be coming after a lot of these manufacturers that are making compounded substances. In a press release distributed last week, Novo Nordisk cited trademark issues and safety concerns and said it is taking steps to protect US patients from the unlawful marketing and sales of non-FDA approved counterfeit and compounded semaglutide products claiming to contain semaglutide, while reinforcing the responsible use of Novo Nordisks FDA-approved medicines. Novo Nordisk has commenced the filing of legal actions in the US against certain medical spas, weight loss or wellness clinics, and compounding pharmacies to cease and desist from false advertising, trademark infringement and/or unlawful sales of non-FDA approved compounded products claiming to contain semaglutide, said the release

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Alongside their weight-loss effects by inhibiting appetite, GLP-1 receptor agonists also lead to reductions in lean body mass, including muscle and supportive fat pads, which can result in unintended effects: hollowing of the face, softening of the jawline, loss of core strength, or laxity in the neck and lower face
Demand for GLP-1 medications is booming, but healthy, sustained weight loss takes more than just medication
Malhotra adds that long-term cost-effectiveness should be evaluated, asking, Is it worth it to put people on these medications, or are there cheaper ways of achieving that same results, which, right now, I dont know what that would be